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on the use of Neolink for the treatment of mastitis in cows, mares, camels, ewes and goats
(Organization-developer: LLC Firm “Biochempharm”, Vladimir region, Raduzhny)


I. General information

1. Trade name of the drug: Neolink.

International nonproprietary name: neomycin sulfate, lincomycin hydrochloride, prednisone.

2. The dosage form of the drug is a suspension for topical use.

Neolink in 1 ml contains as active substances neomycin sulfate -15 mg, lincomycin hydrochloride-20 mg, prednisolone -1 mg ointment-based.

In appearance, Neolink is an oil suspension of white or white-yellow color with a specific smell.

3. The drug is produced packaged in plastic syringes-dispensers, with a capacity of 10 ml or glass bottles with a capacity of 50 or 100 ml, capped with rubber plugs and reinforced with aluminum caps. Other packing providing safety and quality of a preparation and coordinated in accordance with the established procedure is allowed. The packing unit is marked in accordance with the regulatory documentation and is provided with a temporary instruction on the use of the drug.

4. The drug is stored in a dry and dark place at a temperature of 5°C to 20°C. shelf life of the drug 2 years from the date of production.

5. The drug should be stored in places not accessible to children.

6. Neolink should not be used after the expiration date.

II. Pharmacological properties

7. Pharmacotherapeutic group of the drug: combined antibacterial agents.

Neolink has bacteriostatic action against gram-positive and gram-negative microorganisms.

Lincomycin is an antibiotic from the lincosamide group. The antibiotic produced by Streptomyces lincolniensis has a bacteriostatic effect. Inhibits protein synthesis of bacteria due to reversible binding to the 50s ribosome subunit, disrupts the formation of peptide bonds. Active against gram-positive cocci (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis, Mycoplasma spp., Bacteroides spp., Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani. Effective against Staphylococcus spp., resistant to penicillin, tetracyclines, chloramphenicol, streptomycin, cephalosporins (30% Staphylococcus spp., resistant to erythromycin, have cross-resistance to lincomycin). Does not act on Enterococcus spp (including Enterococcus faecalis), gram-negative microorganisms, fungi, viruses, protozoa; inferior in activity to erythromycin against spore-forming anaerobes, Neisseria spp., Corynebacterium spp. Resistance to lincomycin develops slowly. In high doses, it has a bactericidal effect.

Neomycin has a broad spectrum of antibacterial action. It is effective against a number of gram-positive (staphylococci, pneumococci, etc.) and gram-negative (E. coli, dysentery, Proteus, etc.) microorganisms. Against streptococci inactive. On pathogenic (pathogenic) fungi, viruses and anaerobic flora (microorganisms that can exist in the absence of oxygen) does not work. Resistance of microorganisms to neomycin develops slowly and to a small extent. The drug acts bactericidal (destroys bacteria). neomycin is used locally to treat infected wounds, a number of skin diseases (pyoderma), vaginal infections, eye diseases, etc.

Prednisolone, which is part of the Neolink, causes its antitoxic properties, contributing to the rapid removal of inflammatory and allergic reactions, as well as the regeneration of the affected udder tissues.

III. The order of application

8. Neolink is used for the prevention and treatment of mastitis in cows, mares, camels, ewes and goats.

9. Contraindications to the use of the drug is an individual hypersensitivity to its components.

10. Before the introduction of the drug from the patient quarter of the udder is milked secret, and the nipple is disinfected with 70% ethanol.

The drug before use is heated to 35°C -37°C, recruited from the bottle with a sterile syringe and with the help of a catheter injected into the nipple of the affected udder lobe.

When using a syringe dispenser, the syringe catheter is inserted into the nipple canal, the cannula is tightly pressed to the opening of the nipple canal and the drug is injected by gently pressing the piston.

The drug is prescribed in the following doses.

For preventive purposes:

– in the dry period-5 cm3 once, 3 weeks before delivery;    

For therapeutic purposes:

– with hidden forms of mastitis-5 cm3, one or two times;

– with serous, catarrhal, purulent-catarrhal mastitis-10 cm3 at intervals of 24 hours for 4-6 days, with prolonged pathologies-until recovery.

After the introduction conduct a gentle massage of the nipple upwards for a better distribution of the drug. After administration of the drug, milk from the affected udder lobe should not be diluted for at least 6 hours.

11. Symptoms of overdose in the appointment of the drug in accordance with the order of application is not noted.

12. Features of action of Neolink at the first reception or at its cancellation is not established.

13. You should avoid skipping the next dose of the drug, as this can lead to a decrease in therapeutic efficacy. In case of missing one dose of the drug is resumed in the same dosage and according to the same scheme.

14. Side effects in the application of the drug is not established.

15. The use of Neolink does not exclude the use of other drugs.

16. Milk can be used for food purposes not earlier than 3 days (6 milkings) after the last application of the drug. Milk obtained earlier than this period can be used after heat treatment for animal feeding.

Slaughter of animals for meat is allowed not earlier than 7 days after the last administration of the drug. In the case of forced slaughter before the deadline, the meat can be used for food carnivores.


IV. Measures of personal prevention.

17. When working with Neolink, the General rules of personal hygiene and safety, provided for when working with medicines, should be observed.

18. When working with the drug, it is forbidden to drink, smoke and eat. After working with the drug, wash your hands with soap and water. In case of poisoning or allergic reactions, you should immediately contact a medical institution (you should have the instructions for the use of the drug or the label).

19. In case of contact with the skin and/or mucous membranes, it is recommended to wash them with plenty of running water. In case of accidental ingestion – give the victim to drink a large amount of water (4-5 glasses) and cause vomiting.

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