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on the use of Mastodynon

for the treatment of mastitis in lactating cows, mares, camels, sheep and goats

 (Organization-developer: LLC Firm “Biochempharm”, 600910, Vladimir region, rainbow, quarter 16, box 74).

I. General information

1. Trade name: Mastodynon.

International nonproprietary name: benzylpenicillin, neomycin, procaine penicillin, dihydrostreptomycin, prednisone.

2. Dosage form: suspension for topical use.

Mastodynon as the active substance contains in 1 ml of the drug contains 10 mg of benzylpenicillin sodium, 10.5 mg of neomycin sulfate, 10000 IU of procaine penicillin, 10 mg of dihydrostreptomycin sulfate, 1 mg of prednisolone and excipients.

3. Description of the appearance of the drug: in appearance, the drug is a viscous suspension of white or yellowish-white color.

Shelf life of Mastodynon under storage conditions-2 years from the date of production; after opening the bottle-no more than 25 days. Do not use the drug after the expiration date.

4. Form of release of the drug: Mastodynon is produced packaged by 10 cm3 in syringes dispensers made of polymeric material and by 50 cm3, 100 cm3 and 200 cm3 in sterile glass vials of appropriate capacity, capped with rubber stoppers, reinforced aluminum caps.

Each unit of consumer packaging is marked with: the manufacturer, its address and trademark, name, purpose and method of use of the drug, the name and content of the active substance, the volume of the drug in the bottle, the inscriptions “for veterinary use”, series number, date of manufacture, shelf life, storage conditions, state registration number, information on confirmation of compliance, designation of TU and provide instructions for use.

5. Storage conditions: Mastodynon is stored in a sealed container in a dry place, protected from direct sunlight, separately from food and feed, at a temperature of 5°C to 25°C.

6. Mastodynon should be stored out of the reach of children.

7. Unused medicinal product with expired shelf life is disposed of in accordance with the requirements of the legislation.

8. Is dispensed without prescription veterinary doctor.


II. Pharmacological properties

9. Pharmacotherapeutic group of the medicinal product: anti-microbial agents in the combinations.

10. Pharmacokinetics and pharmacodynamics. The complex of antibiotics (benzylpenicillin, neomycin, penicillin procaine, dihydrostreptomycin), included in the preparation, has a bactericidal effect against the most commonly isolated gram-positive and gram-negative microorganisms in mastitis: Staphylococcus, Streptococcus, Corynebacterium and Escherichia. Penicillins inhibit bacterial cell wall synthesis by inactivating the enzyme; neomycin sulfate inhibits protein synthesis at the level of the ribosomal subunit 30S, thus violating the integrity of the bacterial cell wall, thus exerting a bactericidal effect. Dihydrostreptomycin provides the effect of the drug on the E. coli, resistant to neomycin, and simultaneously potentiates the effect of penicillin on streptococcal microflora, and prednisolone, which is part of the drug, has a pronounced anti-inflammatory effect, reducing swelling and tissue soreness.

III. The order of application

11. Indications for use: Mastodynon is used to treat mastitis in lactating cows, mares, camels, sheep and goats caused by gram-positive and gram-negative microorganisms, including Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysagalactiae, Streptococcus uberis and Escherichia coli.

12. Contraindications: individual intolerance of the drug components.

13. Dosing regimen, method of administration and application. Mastodinon is administered intracisternally (vnutrivenno). Before using the drug, milk (secret) from patients with udder lobes is milked completely and disposed of. The diseased portion of the udder and the nipple are washed with warm water and soap and dried with a sterile gauze cloth, then a syringe cannula is inserted into the nipple canal and the contents are gently squeezed out. Cows, mares, camels are injected with 10 cm3 (the contents of 1 syringe), sheep and goats-5 cm3 (the contents of 1/2 syringe). After that, the cannula is removed, the tip of the nipple is squeezed with fingers and gently massage the nipple from the bottom up for 1-2 minutes for better distribution of the drug. In severe mastitis administration of the drug is repeated after 24 or 48 hours.

The drug, packaged in vials, is recruited with a sterile syringe and with the help of a catheter administered in the above doses to the nipple of the affected udder lobe similarly to the use of syringe-dispensers.

14. Symptoms of overdose, measures to provide assistance in case of overdose: symptoms of overdose in animals have not been identified.

15. Peculiarities of action of the medicinal product for veterinary use at first use or withdrawal thereof: not applicable.

16. The possibility and features of use in pregnant animals, in animals during lactation, in the offspring of animals: local use of Mastodynon does not have a negative impact on the course of pregnancy, lactation and development of offspring in animals.

17. Description of actions veterinary doctor( veterinary paramedic), conjures practitioner in area veterinary, owner animal under omission reception one or several doses drug for veterinary use of: should avoid omission the introduction of another doses of drug, so as this may lead to reduce therapeutic efficiency. In case of missing one dose of the drug is resumed in the same dosage and according to the same scheme.

18. Possible side effects, adverse reactions in the application of the drug for veterinary use: in the application of Mastodynon side effects and complications, as a rule, is not observed. With increased individual sensitivity of the animal to quinoxaline derivatives, the use of the drug is discontinued and desensitizing therapy is performed.

19. Interaction with other drugs and (or) feed: if necessary, Mastodynon is used simultaneously with antihistamines or calcium preparations (with increased sensitivity to drugs).

20. Terms of possible use of products of animal origin after the introduction of the animal drug for veterinary use. During the treatment, milk from all udder lobes must be disposed of, for food purposes it is allowed to use milk 72 hours after the last administration of Mastodynon. Slaughter of animals for meat is allowed not earlier than 7 days. Meat of slaughtered animals to the expiration of the term shall be used to feed fur animals. Syringes from under the drug should be disposed of with household waste.

IV. Personal prevention measures

21. Precautions for use: when working with Mastodynon should follow the General rules of personal hygiene and safety, provided when working with drugs.

22. Observance of precautions, rules of personal hygiene, use of protective equipment when working with the drug: when working with the drug, it is forbidden to drink, smoke and eat. After working with the drug, wash your hands with soap and water. It is forbidden to use bottles from under the drug for household purposes.

23. First aid to victims: if the drug gets on the skin and mucous membranes, rinse them with plenty of tap water. People with hypersensitivity to tetracyclines should avoid direct contact with the drug. In case of accidental ingestion of the drug into the human body or manifestations of allergic reactions, you should immediately contact a medical institution (you should have the instructions for use of the drug and the label).

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