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the use of the drug Madrasatul-And

for the treatment and prevention of endometritis in cows

(Organization-developer: LLC Firm “Biochempharm”, Vladimir region, Raduzhny)

I. General information

1. Trade name of the medicinal product: Madrasatul-A.

International nonproprietary name: tylosin tartrate, neomycin, carbacholine, β-carotene.

2. Dosage form: topical solution. The drug in its composition as active substances contains in 1 ml: tylosin tartrate-5 mg, neomycin-10 mg (in the form of neomycin sulfate), carbacholine – 0.03 mg, β-carotene – 0.8 mg, and as excipients 1.2-propylene glycol 360 mg, distilled water – up to 1 ml.

Madrasatul-A is a solution of orange color with a weak specific smell. The drug is produced packaged in 1 liter cans of polymer material with screw caps and control of the first opening and syringes Jean, equipped with a polystyrene pipette for intrauterine administration.

3. Each package is marked with an indication of the manufacturer, its address and trademark, the name of the drug, the name and content of active substances, series number, date of manufacture and shelf life (month, year), storage conditions, the amount in the bottle or canister, the inscription “for veterinary use”, designation TU and provide instructions for use.

Store the drug in a closed package of the manufacturer, in a dry, protected from light place at a temperature of 5°C to 25°C.

4. Shelf life of the drug under the conditions of storage in a closed package – 2 years from the date of production. After opening the canister, the drug can be stored for 28 days. Do not use Metraseptol-A after the expiration date.

5. Madrasatul And should be stored in places inaccessible to children.

6. Unused in the opened cans of the drug and the drug with an expired shelf life is disposed of in accordance with the requirements of the legislation.

II. Pharmacological properties

7. Madrasatul And belongs to the pharmacotherapeutic group of complex antimicrobials.
Included in the drug tylosin tartrate has an antimicrobial effect against gram-positive (cocci, carinobacteria, Clostridium, erizipelotriksov) and some gram-negative microorganisms (Pasteurella, Hemophilus, Brucella), vibrions, leptospir, neyserium, Rickettsia, spirochetes, Mycoplasma, large basophilic viruses psittakosis group.
Carbacholine enhances the contractility of the uterine myometrium, which contributes to better evacuation of the afterbirth and exudate in endometritis, rapid recovery of its original size after calving.
An aqueous solution of beta-carotene promotes rapid regeneration of the uterine mucosa.
The components included in the preparation are poorly absorbed by the uterine mucosa, which prevents their accumulation in animal products. The drug is low-toxic for warm-blooded animals (hazard class 4), in the recommended doses does not have a locally irritating and sensitizing effect.

III. The order of application

8. The drug is used for the treatment and prevention of endometritis in cows.
9. Contraindications to the use of Madrasatul is increased individual animal sensitivity to the preparation components.
10. Before the introduction of the drug, sanitary treatment of the external genitals is carried out. If necessary, release the uterine cavity from inflammatory exudate.
Metraseptol – a is preheated to a temperature of 35-40°C, the contents of the vial are thoroughly shaken until a homogeneous emulsion is obtained and injected with a syringe intrauterine Janet as follows:
– with purulent-catarrhal endometritis-20 ml per 100 kg of weight at intervals of 48-72 hours (100-150 ml per cow);
– in subclinical endometritis intrauterine-10-20 ml / 100 kg of weight 8-12 hours after insemination (sanitation of the uterine cavity);
– in chronic endometritis-20-60 ml / 100 kg of weight at intervals of 72 hours 2-3 times.
For the prevention of postpartum obstetric diseases, after the separation of the afterbirth, abortion or care for complications and pathological childbirth, the drug is used once intrauterine dose of 50 – 150 ml per animal.
11. Symptoms of drug overdose have not been established.
12. Features of the drug at its first use and cancellation is not established.
13. Failure to follow the recommended interval for repeated administration of the drug may lead to a decrease in its effectiveness. If you miss the next dose of the drug, its use is resumed as soon as possible in the same dosage and according to the same scheme.
14. In recommended doses, Madrasatul And does not cause side effects in animals and complications.
15. The use of Metraseptol-A does not preclude the use of other drugs.  

16. Slaughter for meat is allowed no earlier than 72 hours, and the use of milk in human food – 48 hours after the last use of the drug.

IV. Measures of personal prevention.

17. When working with Metraseptol-A, the General rules of personal hygiene and safety provided for when working with medicines should be observed.

18. When working with the drug, it is forbidden to drink, smoke and eat. After working with the drug, wash your hands with soap and water. In case of poisoning or allergic reactions, you should immediately contact a medical institution (you should have the instructions for the use of the drug or the label).

19. In case of contact with the skin and/or mucous membranes, it is recommended to wash them with plenty of running water. In case of accidental ingestion – give the victim to drink a large amount of water (4-5 glasses) and cause vomiting. In case of allergic reactions, you should immediately contact a medical institution (you should have the instructions for use of the drug and the label).

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