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on application of the METRICID preparation for treatment of endometritis at farm animals (the developer Organization: LLC biochempharm Firm, 600910, Vladimir region, Raduzhny, quarter 16, box 74)

I. General information

1. Trade name of the drug: Metricide.

International nonproprietary name: Ceftriaxone, prednisone.

2. Dosage form: suspension.

1 ml of the drug contains as the active substance Ceftriaxone-100 mg, prednisolone-0.05 g, as well as excipients: vaseline oil, stearic acid and aluminum stearate.

3. In appearance, the drug is a viscous suspension of white or yellowish-white color. During storage, it is allowed to peel off a transparent layer of liquid, shaking the drug restores uniformity.

Shelf life Metricide under storage conditions-3 years from the date of production, after the first opening of the syringe-no more than 25 days. Do not use the drug after the expiration date.

4. The drug is produced packaged in syringes of 20.0 ml, equipped with a polystyrene pipette for intrauterine administration and a glove for rectal fixation of the cervix. Syringes are Packed in 20 pieces in cardboard boxes along with instructions for use.

5. Store the drug in the closed packaging of the manufacturer, in a dry dark place, at a temperature of 2 °C to 25°C.

6. Metricide should be stored out of the reach of children.

7. Unused product with expired shelf life is disposed of in accordance with the legislation.

8. Is dispensed without prescription veterinary doctor.

II. Pharmacological properties

9. Pharmacotherapeutic group of the drug: antibacterial drugs for topical use in gynecology.

10. Metricide has a combined antibacterial effect. The consistency of the dosage form of the drug contributes to its uniform distribution over the mucous membrane of the affected organ, the transport of active components to the pathological focus and the maximum contact of active components with the lesion.

Ceftriaxone belongs to the second generation of cephalosporin antibiotics and has a broad spectrum of bactericidal action against actinomycetes, gram-positive and some gram-negative bacteria, including Staphylococcus pneumoniae, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. Ceftriaxone interferes with the synthesis of the bacterial cell wall, inhibits the enzymes of transpeptidase and carboxypeptidase and causes a violation of the osmotic balance, which leads to the death of the bacteria at the growth stage. The antibiotic is resistant to the enzyme penicillinase and retains its activity in anaerobic and aerobic conditions. With intrauterine use of Ceftriaxone from the dosage form easily penetrates into the endometrial tissue, where it provides a minimum inhibitory concentration for 24 hours.

Prednisolone has anti-inflammatory and mild analgesic effect.

The consistency of the dosage form of the drug contributes to its uniform distribution over the mucous membrane of the affected organ, the transport of active components to the pathological focus and the maximum contact of active components with the lesion.

Metricide on the degree of impact on the body to treat moderately hazardous substances (hazard class 3 according to GOST 12. 1. 007).

III. The order of application

11. Metricide is used for the prevention and treatment of endometritis in cows, mares, camels, sows, ewes and goats. Especially effective against chronic and subacute forms.

12. Contraindicated in animals with increased individual sensitivity to cephalosporins. It is forbidden to use Metricide during pregnancy and in the first 14 days after birth.

13. Before the introduction of the drug, sanitary treatment of the external genitals and the root of the tail is carried out. If necessary, release the uterine cavity from inflammatory exudate.

Before the introduction of Metricide is recommended to heat up to 35°C-40°C intensively shake.

For the introduction of Metricide, the syringe is connected to an intrauterine pipette with a special nozzle, a hand in a glove of single use rectally fix the cervix, then carefully insert the pipette through the neck into the uterine cavity and squeeze out the contents of the syringe.

The drug is administered once in the uterine cavity: cows, mares, camels – in a dose of 20 ml (the contents of one syringe), sows – 10 ml (the contents of ½ syringe), sheep and goats – 5 ml (the contents of ¼ syringe). If the cause of repeated “peregulov” is chronic endometritis, then Metricide is used either 3-4 days before insemination or the next day after insemination. If necessary, the introduction can be repeated after 24 hours.

14. Symptoms of overdose when using the drug in accordance with this instruction is not established.

15. Features of the drug for veterinary use at the first reception or at its cancellation is not established.

16. Metricide should not be used in pregnant animals and in the first 14 days after birth.

17. The drug is used once as needed.

18. Side effects and complications with proper use and dosage of the drug is not observed. Animals sensitive to metricide may have allergic reactions. In case manifestations of have animal signs of individual heightened sensitivity to drug in the early treatment, his the use of should abolish and to appoint means symptomatic therapy.

19. The use of Metricide does not exclude the use of other drugs specific, pathogenetic and symptomatic therapy.

20. Milk obtained from animals during treatment with Metricide and within 2 days after the last administration of the drug, it is forbidden to use for food purposes.

Slaughter of animals for meat is allowed not earlier than 7 days after the last administration of the drug. Meat of animals forcibly killed before the expiration of this period can be used for feeding fur-bearing animals.

IV. Personal prevention measures

21. When working with Metricide, the General rules of personal hygiene and safety provided for when working with medicines should be observed.

22. When working with the drug, it is forbidden to drink, smoke and eat. After working with Metricide, wash your hands with soap and water.

In case of contact with the skin and mucous membranes should be washed with plenty of tap water. People with hypersensitivity to Metricide components should avoid direct contact with the drug. In case of allergic reactions and / or accidental ingestion of the drug in the human body should immediately contact a medical institution.

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