INSTRUCTION
on the application of Enrosan 5% injection solution
for the treatment of diseases of calves, pigs
and dogs bacterial etiology
(Organization-developer: LLC Firm “Biochempharm”, Raduzhny, Vladimir region.)
I. General information
1.Trade name of the drug: Enrosan 5% solution for injection.
International nonproprietary name: enrofloxacin (Enrofloxacin).
2. Dosage form: solution for injection. 1 ml of the solution contains 50 mg of enrofloxacin. In appearance, the drug is a transparent solution of light yellow color.
Enrosan 5% solution for injection is available sterile packaged in 10, 50 and 100 ml in bottles of brown glass or bottles of opaque polymer material, capped with rubber stoppers, reinforced aluminum caps. Other packing agreed in accordance with the established procedure is allowed.
3. Shelf life of the drug under storage conditions-3 years from the date of production. Do not use the medicine after its expiration date.
4. The drug is stored in a dry, dark place, at a temperature of 5°C to 25°C.
5. Endosan 5% solution for injection should be stored in places inaccessible to children.
6. Unused product with expired shelf life is disposed of in accordance with the requirements of the legislation.
II. Pharmacological properties
7. Pharmacotherapeutic group: antibiotic of the fluoroquinolone. Enrofloxacin, which is the active ingredient of Enrosan, inhibits the DNA gyrase of bacteria, thereby disrupting the process of DNA replication, as a result of which microorganisms can not reproduce. Enrofloxacin is rapidly absorbed into the blood and penetrates into all organs and tissues of the body. The maximum concentration of the drug in the blood is achieved after 1.5-2 hours and remains for 6 hours, and the therapeutic concentration – for 24 hours.
The drug is mainly excreted in the urine and bile.
When a combination of Enrosan 5% solution for injection with chloramphenicol, macrolides or tetracycline, antagonistic effects may be observed.
Do not administer simultaneously with non-steroidal anti-inflammatory drugs and theophylline.
Enrofloxacin 5% solution for injection the solution of exposure to the body refers to moderately dangerous substances (hazard class 3 according to GOST 12.1.007-76), in the recommended doses is well tolerated by animals, does not have a locally irritating effect, does not have embryotoxic, teratogenic and hepatotoxic properties.
III. The order of application
8. Enrosan 5% solution for injection is used for the treatment of infectious diseases of the respiratory system, gastrointestinal tract, genitourinary system, skin, mastitis caused by bacteria and Mycoplasma, as well as secondary bacterial infections in viral diseases in cattle, camels, sheep, goats and other ruminants, pigs, dogs, cats, fur-bearing animals, rabbits and other animals caused by the following gram-positive and gram-negative bacteria and Mycoplasma sensitive to enrofloxacin: E. coli, Haemophilus, pasterella, mysoplasma bovis, Staphylococcus, etc.
9. Enrosan 5% solution for injection is not allowed to be used in the following cases:
– for the treatment of dogs under 12 months of age or before the end of the growth period;
– for the treatment of females during pregnancy;
– with significant violations of the development of cartilage;
– with lesions of the nervous system, accompanied by convulsions;
– in the presence of microorganisms resistant to quinolones;
– dogs cannot be simultaneously appoint teofillin;
– together with nonsteroidal anti-inflammatory drugs
– in case of individual hypersensitivity to the components of the drug.
10. Endosan 5% solution for injection is administered to calves, sheep, goats, dogs and cats subcutaneously, to pigs – intramuscularly in doses of:
* young ruminants (calves, camels, sheep, goats and others), pigs, rabbits-1 ml per 20 kg of animal weight (2.5 mg enrofloxacin per 1 kg of weight) once a day for 3-5 days, and in the treatment of mastitis-metritis-agalactic syndrome for 1-2 days;
* dogs, cats, fur animals – 1 ml per 10 kg of animal weight (5 mg enrofloxacin per 1 kg of weight) once a day for 5 days in a row, and in chronic and severe diseases up to 10 days.
In the absence of clinical improvement within 3 days, it is recommended to test for the sensitivity of microorganisms to fluoroquinolones or replace Enrosan with another antibacterial drug.
In connection with the possible pain reaction, the drug should be administered in an amount of not more than 5 ml in one place to calves, camels and pigs and not more than 2.5 ml to pigs, lambs, goats, dogs, cats, fur-bearing animals and rabbits.
11. When using Enrosan 5% solution for injection in accordance with this instruction, there are no symptoms of overdose.
12. Features of the drug at the beginning of use or when it is canceled is not revealed.
13. You should avoid skipping the next dose of the drug, as this can lead to a decrease in therapeutic efficacy. In the case of skipping one or more doses of the drug as soon as possible resume in the same dosage and according to the same scheme.
14. With increased individual sensitivity of the animal to enrofloxacin and adverse events (feed refusal, vomiting, impaired coordination of movements) use of the drug is stopped.
15. The drug is not recommended for use simultaneously with bacteriostatic antibiotics (levomitsetinom, macrolides and tetracyclines), Theophilus and nonsteroidal anti-inflammatory drugs because of the possible antagonistic effect.
16. Slaughter of animals for meat is allowed not earlier than 11 days after the last use of the drug.
Meat animals, forced killed before the deadline, can be used to feed flesh eaters or for production of tankage.
IV. Personal prevention measures
17. When working with Enrosan 5% solution for injection and should follow the General rules of personal hygiene and safety provided when working with drugs. At the end of work hands should be washed with warm water and soap.
18. When working with the drug, it is forbidden to drink, smoke and eat. After working with the drug, wash your hands with soap and water.
19. In case of contact with the skin and/or mucous membranes, it is recommended to wash them with plenty of running water. In case of accidental ingestion – give the victim to drink a large amount of water (4 – 5 glasses) and cause vomiting. In case of allergic reactions, you should immediately contact a medical institution (you should have the instructions for use of the drug and the label).
