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for use of the veterinary drug ” Guiteroton 5»

1 General information

1.1 Heterodon 5 (Giteroton 5). Chemical name: 2[Aminocarbonyl] – N, N, N three methylethanaminium chloride, sodium chloride.

1.2 Dosage form: solution for injection.

1.3 the Preparation in 100 ml contains as active substances: 2 [Aminocarbonyl] – N, N, N three methylethanaminium chloride-50 mg and sodium chloride-900 mg, and as an auxiliary substance – water for injection.

1.4 Guiterotone 5 in appearance is a colorless transparent liquid.

1.5 Produce the drug packaged in 100 ml in glass bottles of the appropriate capacity, capped with rubber stoppers, reinforced with aluminum caps. Each consumer package is accompanied by instructions for use.

1.6 The Drug is stored according to list A in the manufacturer’s closed packaging, in a place protected from direct sunlight, separate from food and feed, at a temperature of plus 5 ° C to plus 25 ° C.

1.7 Heterodon 5 should be stored in places inaccessible to children.

1.8 shelf life of the drug under the conditions of storage in a closed package – 3 years from the date of production. After the first opening of the bottle, the drug should be used within 12 hours. Do not use the drug after the expiration date. Unused medication is disposed of in accordance with the requirements of the legislation. It is available on the prescription of a veterinarian.

2 Pharmacological properties

2.1 Guiterotone 5 belongs to the pharmacotherapeutic group of M – and N-cholinomimetics.

2.2 2[Aminocarbonyl] – N, N, N tri methylethanaminium chloride, the active substance of the drug, is a synthetic derivative of choline, affects the peripheral cholinergic structures, stimulating the endings of M – and N-cholinergic receptors (cholinomimetic), increases the contraction of the smooth muscles of the uterus, gastrointestinal tract, bladder and other organs. It does not penetrate the blood-brain and placental barriers.

2.3 the effect of the drug occurs 10-15 minutes after subcutaneous or intramuscular administration and lasts for several hours. 2[Aminocarbonyl] – N, N, N tri methylethanaminium chloride is not hydrolyzed by acetylcholinesterase in the body and therefore has a longer lasting effect compared to acetylcholine.

2.4 the Drug in the recommended doses does not have a local irritant, resorptive or sensitizing effect.

3 application Procedure

3.1 Giteroton 5 is used in cows and pigs for the treatment of uterine subinvolution, endometritis and metritis of various etiologies, weakness of labor, retention of the afterbirth, atony and hypotension of the pre-ventricles and intestines, and bladder.

3.2 the Drug is prescribed subcutaneously or intramuscularly in the following doses:


– when the afterbirth is delayed-1.5 ml per 100 kg of animal body weight (no more than 8.0 ml per administration to one animal) 3-4 hours after the removal of the fetus(s), and then again-24 hours later;

– for the prevention of postpartum diseases (subinvolution of the uterus, endometritis, metritis) – 2.0 ml per 100 kg of animal body weight (no more than 8.0 ml per administration to one animal) 3-5 injections at intervals of 24-72 hours.

for treatment of endometritis and metritis of various etiologies-1.5 ml per 100 kg of animal body weight, three times, with an interval of 48 hours. To improve the contractile function of the myometrium to liberate the uterus from the content (exudate) for 10-12 hours prior to the introduction into the uterine cavity preparations and again 24 hours after administration of the same dose (when calculating the dose necessary to take into account the presence of intrauterine uterotonic drugs active ingredients);

– for ovarian cysts in a complex treatment regimen-1.0 ml per 100 kg of animal body weight, twice, with an interval of 72 hours;

– for weak labor (weak contractions and attempts) – 0.8 ml per 100 kg of body weight of the animal, three times, with an interval of 1 hour;


– when the afterbirth is delayed, endometritis and metritis of various etiologies, weakness of labor (weak contractions and attempts), the drug is administered subcutaneously at a dose of 0.05-0.10 ml per 10 kg of animal body weight.

It is not allowed to use the drug more often than 1 time in 24 hours, do not exceed the recommended dosage (the maximum dose for administration to one cow is 8 ml, to a sow – 4 ml).

3.3 in case of overdose and in weakened animals, there may be phenomena in the form of shortness of breath, enteritis, drooling, anxiety, narrowing of the pupils, which pass independently after 7-12 hours. If this does not happen, atropine sulfate is administered at a dose of 5.0 mg per 100 kg of animal body weight. Administration of the drug may cause painful irritation at the injection site.

3.4 Contraindication to the use of the drug is individual hypersensitivity of the animal to the components of the drug. Giteroton 5 can not be used in animals that have an overflowing gastrointestinal tract with tympanum, convulsions, heart and respiratory diseases, acute infectious diseases. With caution-an emaciated animal.

3.5 Features of the action at the first administration of the drug and at its cancellation were not revealed.

3.6 Giteroton 5 is contraindicated in pregnant animals.

3.7 skipping administration of the drug Should be avoided, as this may lead to a decrease in its therapeutic effectiveness.

3.8 there May be rare cases of hypersensitivity to the components of the drug. In case of anaphylactic reaction in an animal, immediately enter subcutaneously 0.1 % solution of epinephrine at the rate of 0.03-0.05 ml/kg of live weight of the animal. According to indications to use of atropine, diphenhydramine and caffeine.

3.9 Guiterotone 5 is not recommended to be used simultaneously with other myotonic agents. The drug can not be used in conjunction with cholinomimetics and anticholinesterase agents.

3.10 during and after the use of the drug, animal products can be used without restrictions.

4 prevention Measures

4.1 when working with the product, follow the rules of personal hygiene and safety provided for when working with medicines.

4.2 in case of accidental contact with the skin or eye mucosa, rinse immediately with plenty of water. In case of allergic reactions or accidental ingestion of the drug in the human body, you should immediately contact a medical institution (have the instructions for use of the drug or the label).


5.1 in case of complications after the use of the drug, its use is stopped and the consumer applies to the State veterinary institution on the territory of which he is located. Veterinary specialists of this institution study compliance with all the rules for the use of the drug in accordance with the instructions. When confirming the detection of a negative effect of the drug on the animal body or the drug does not match in appearance, veterinary specialists take samples in the required amount for laboratory tests, and send them to the state institution “Belarusian state veterinary center” (220005, Minsk, Krasnaya str., 19a) to confirm the drug’s compliance with regulatory documentation.

6 full name of the MANUFACTURER

6.1 LLC Firm “Biohimpharm”, 600014, Russia, Vladimir region, Raduzhny, block 16, a/z 74.
Instructions for use of the drug were prepared by employees of LLC Firm ” Biohimpharm “(Kostyrkin Yu.a.) and UO” Vitebsk state Academy of veterinary medicine ” (Kuzmich R. G., Yatusevich D. S.) on the basis of the dossier submitted by the manufacturer.

Permanent link to this article: http://biohimfarm.ru/en/novosti/giteroton5/