Print this Post



on the use of the drug “Trimeratim BHF powder” for the treatment of infectious diseases of bacterial etiology in animals

(organization-developer: LLC Firm “Biochempharm”, Raduzhny, Vladimir region).

I. General information

1. Trade name of the medicinal product: Trimurti BHF powder.

International nonproprietary name: sulfamethoxazole, trimethoprim.

2. Dosage form: powder.

In appearance, the preparation Trimeratim BHF powder is a homogeneous fine-crystalline powder from white to cream.

As active ingredients Trimeratim BHF powder in 1 g of powder contains 0, 12 g of the active substance (0.1 g sulfamethoxazole and 0.02 g trimethoprim).

Trimeratim BHF powder is produced packaged in 0.2; 0.3; 0.5; 1.0; 2.0 kg in double bags of polyethylene film, in polymer bags or polymer cans of appropriate capacity.

3. Shelf life Trimeratima BHF powder under storage and transportation conditions-3 years from the date of production. Never use Timeritem BHF powder is past its expiration date.

4. Store the drug in a closed package of the manufacturer, in a dry place protected from light at a temperature of 0C to 25C.

5. Timeritem BHF powder should be stored in places inaccessible to children.

6. Unused and expired medicinal product shall be disposed of in accordance with the applicable legislation.

II.Pharmacological properties

7. Pharmacotherapeutic group of the medicinal product: a combination of antibacterial drugs.

Trimeratim BHF powder is a preparation with a wide spectrum of synergistic bactericidal action of components on gram-positive and gram-negative microorganisms. It is especially active against Haemophilus, Escherichia coli, proteus mirabilis and vulgaris. The mechanism of action of the drug is to inhibit each component of the activity of two different enzymes involved in the biosynthesis of folic acid bacteria.

The synergistic effect of sulfametoxazole and trimethoprim, which are part of the drug, is due to the sequential blockade of microbial cell enzymes: sulfametoxazole disrupts the synthesis of dihydrofolic acid, and trimethoprim blocks the next stage of bacterial metabolism – the restoration of dihydrofolic acid to tetrahydrofolic acid, which is necessary for the development of microorganisms. Trimerised when administered orally is rapidly absorbed in the gastrointestinal tract and penetrates into organs and tissues of the animal. Therapeutic concentration of the drug in organs and tissues after a single administration is achieved in 2 – 4 hours and is maintained for 12 hours. The drug is excreted from the body mainly with urine and partially with bile, saliva and milk.

The drug on the degree of exposure to the body of warm-blooded refers to substances moderately dangerous (hazard class 3 according to GOST 12.1.007).

III. The order of application

8. The drug is used for bacterial infections of the urinary tract and kidneys, upper respiratory tract infections and inflammatory conditions of the lungs, skin infections and digestive tract, especially salmonellosis and colibacteriosis.

In preoperative and postoperative, as well as posttraumatic infections, sepsis, toxoplasmosis and mycoplasmosis, acute inflammatory conditions as a complementary treatment, as well as bacterial complications during viral diseases.

9. Contraindications to the use of Trimeratima BHF powder is hypersensitivity to sulfonamide drugs. The drug should not be used in pregnant females and animals with impaired functions of the organs of hematopoiesis, liver and kidneys. It is forbidden to use Trimeratim BHF for dairy cattle.

10. Trimeratim BHF powder is administered orally for 4-6 days 2 times a day at the rate of 5 g per 20 kg of animal weight, which is 30 mg / kg of active substance. The drug is given with food, drinking water or on the root of the tongue.

In the treatment of animals shall be provided with access to water.

11. Symptoms of overdose when using the drug in accordance with this instruction is not established.

12. Features of the drug at the beginning of use or when it is canceled is not revealed.

13. It is necessary to avoid non-observance of the recommended interval at repeated introduction of a preparation and the admission of the next dose as it can lead to decrease in therapeutic efficiency.

14. Side effects and complications in the use of Trimebutine BHF powder is usually not observed. Under heightened individual sensitivity animals to sulfanilamidam are possible loss of appetite, diarrhea and vomiting. The use of the drug in these cases is discontinued.

15. Application Trimebutina BHF does not preclude the use of other drugs. During treatment, novocaine should not be prescribed, as it reduces the antimicrobial effect of the drug. The drug enhances the effect of anticoagulants.

16. Slaughter of animals for meat is allowed not earlier than 15 days after the last use of the drug. In case of forced slaughter before the deadline, the meat can be used for animal feed or for the production of meat and bone meal.

IV. Personal prevention measures

17. When working with Trimeratim BHF powder should comply with the General rules of personal hygiene and safety, provided when working with drugs.

18. When working with the drug, it is forbidden to drink, smoke and eat. After working with the drug, wash your hands with soap and water.

19. In case of contact with the skin and/or mucous membranes, it is recommended to wash them with plenty of running water. In case of accidental ingestion – give the victim to drink a large amount of water (4-5 glasses) and cause vomiting. In case of allergic reactions, you should immediately contact a medical institution (you should have the instructions for use of the drug and the label).

Permanent link to this article: http://biohimfarm.ru/en/antibakter_r/trimeratim/