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of using Tilozin 50 for the treatment of infectious animal diseases of bacterial etiology (organization-developer: “BioKhimPharm”, Raduzhny, Vladimir region). 

1 General Information 

1.1 Tylosin 50 (Tylosinum 50).

1.2 The preparation is a transparent, slightly viscous yellowish liquid with no mechanical impurities.

In 1.0 cm3 of the preparation contains 50 mg of tylosin.

1.3 The preparation is produced in glass bottles of 10, 50 and 100 cm3.

1.4 The drug is stored with caution (List B) at a temperature of plus 5 ° C to plus 25 ° C, in a dry, dark place.

Shelf life 2 (two) years from the date of manufacture, subject to the storage rules.

The shelf life of the drug after opening the bottle is 7 days.

2 Pharmacological properties 

2.1 Tylosin is an antibiotic from the macrolide group. It is active against most Gram-positive and some Gram-negative bacteria: staphylococcus (Staphylococcus), Streptococcus, Corynebacterium, Clostridium, Pasteurella, Erysipelothrix, Fusobacterium, Spirochaetes, Leptospira, Chlamydia, Serpulina hyodysenteriae, Mycoplasma, Treponema hyodysenteriae, Actinomyces pyogenes and some others.

2.2 The mechanism of action of the drug is based on the inhibition of protein synthesis in a microbial cell, by blocking the enzyme translocase.

2.3 With intramuscular injection, tylosin rapidly enters the bloodstream and penetrates almost all organs and tissues, reaching a maximum concentration 1 hour after administration. The highest level of tylosin is reached in the lungs, intestinal wall, liver, breast and kidneys.

After a single injection, the therapeutic concentration of tylosin is maintained in serum for at least 20 hours. Tylosin is excreted from the body mainly with bile, in smaller quantities – with urine and milk.

3 How to use the drug 

3.1 Tylosin 50 is used to treat large and small cattle, pigs, dogs and cats with bronchopneumonia; Enzootic pneumonia, arthritis, dysentery, atrophic rhinitis of pigs; erysipelas, infectious agalactics of sheep and goats, mastitis in cattle and other diseases whose causative agents are sensitive to tylosin.

3.2 The drug is administered to the animal intramuscularly once a day for 3-5 days in the following doses:

– Cattle: 0.8-2.0 cm3 / 10 kg of body weight;

– Pigs: 0.4-2.0 cm3 / 10 kg of body weight;

– Sheep and goats: 1.0-2.0 cm3 / 10 kg of body weight;

– Dogs and cats: 0.4-2.0 cm3 / 10 kg of body weight;

Do not skip the next dose of the drug, as this may lead to a decrease in therapeutic effectiveness. In the case of missing one or more doses, the drug is resumed as soon as possible in the same dosage and according to the same schedule.

It is not recommended to inject large cattle into cattle more than 10 cm3, pigs 5 cm3 of the drug in one place and mix in one syringe with other medicinal preparations.

3.3 Contraindication to the use of the drug is the increased individual sensitivity of the animal to tylosin. The drug is prohibited for horses and lactating animals, whose milk is intended for human consumption.

3.4 It is not recommended simultaneous use of tylosin 50 with drugs from the groups of penicillin, cephalosporin, lincosamide.

3.5 Local reactions may occur at the injection site, allergic reactions in the form of edema of the rectum and vulva, diarrhea, pruritus and erythema on the skin that occur after discontinuation of the drug are possible in pigs. Individual individuals of cattle can have increased respiration and pulse.

3.6 Slaughter of animals for meat is allowed no earlier than 8 days after the last use of the drug. The meat of animals that were forced to die before the expiration of this period can be used for feeding carnivores.

4 Personal prevention measures 

4.1 When working with the drug, you should follow the general rules of personal hygiene and safety.

4.2 Do not use the packaging from the preparation for household purposes.

4.3 The drug should be stored out of the reach of children.

5 The procedure for the presentation of complaints 

5.1 In the event of complications after application of the drug, its use is terminated and the consumer applies to the State Veterinary Institution in whose territory he is located.

Veterinary specialists of this institution make a study of compliance with all rules for the use of the drug in accordance with the instructions. When confirming the negative impact of the drug on the animal’s organism, veterinarians select samples in the required quantity for laboratory tests, write a sampling report and be sent to the State Veterinary Institution for confirmation of compliance with regulatory documents.

Permanent link to this article: http://biohimfarm.ru/en/antibakter_r/tilozin-50/