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of using streptomycin sulfate for injection for the treatment of animals in diseases of bacterial etiology

(Manufacturer: BioKhimPharm, Vladimir Region, Raduzhny)

I. General information

1. Trade name: Streptomycin sulfate for injection (Streptomyсini sulfas pro injectionibus).

International non-proprietary name: streptomycin sulfate (Streptomyсini sulfas).

2. Dosage form: powder.

Streptomycin sulfate for injection as an active substance contains (in terms of dry matter) at least 730 μg / mg streptomycin sulfate.

Streptomycin sulfate for injection is released packaged in glass bottles of 0.5 g or 1.0 g.

3. Shelf life Streptomycin sulfate for injections under the storage conditions is 3 years from the date of manufacture.

It is forbidden to use the medicinal product after the expiry date.

4. Streptomycin sulfate for injection is stored in a sealed manufacturer’s packaging in a dry, protected from light place, separate from food and feed, at a temperature of 5 ° C to 25 ° C.

5. Streptomycin sulfate for injection is stored in places inaccessible to children.

6. No special precaution is required when destroying an unused medicinal product.

II. Pharmacological properties

7. Streptomycin sulfate for injection – an antibacterial agent of the aminoglycoside group.

Streptomycin sulfate is active against many Gram-positive and Gram-negative microorganisms, including staphylococci (Staphylococcus spp.), Pasteurella, Escherichia coli, Salmonella, Campylobacter spp., Leptospira, . Antibiotic does not affect anaerobic bacteria, fungi, viruses and protozoa.

After intramuscular injection of streptomycin, sulfate is rapidly absorbed into the blood, penetrates into the organs and tissues. The maximum concentration of the antibiotic in the blood is reached 30 minutes after the administration and is maintained at the therapeutic level for 10-12 hours. The antibiotic is excreted from the body mainly with urine.

Streptomycin sulfate for injection in terms of the degree of exposure to the body belongs to highly hazardous substances (hazard class 2 according to GOST 12.1.007), does not have a sensitizing effect in the recommended doses.

III. The order of application

8. Streptomycin sulfate for injection is used to treat leptospirosis, edematous disease, pigs erysipelas, campylobacteriosis and actinomycosis of cattle, bronchopneumonia, mastitis, endometritis, wound and postnatal sepsis and other diseases whose pathogens are susceptible to streptomycin.

9. Contraindication to the use of the drug is the increased individual sensitivity of the animal to the antibiotics of the aminoglycoside group.

10. Before use, the preparation in a vial is dissolved in 10 ml of water for injection or sterile isotonic sodium chloride solution.

Streptomycin sulfate for injection is administered intramuscularly at intervals of 12 hours for 4-7 days.

Single doses of the drug are presented in Table 1

Table 1

Kind of animals

Single dose,

mg of active ingredient / kg of animal weight

Single dose,

mg of active ingredient / kg of animal weight


young growth *







Small cattle



Pigs, dogs



Fur Furry Animals




* Note: young cattle and pigs – animals up to 6 months of age, small cattle – up to 4 months of age, horses, dogs and fur animals – up to 1 year. 

When leptospironositelstvo cattle and pigs Streptomycin sulfate for injection administered to animals once a day for three days at a dose of 25 mg / kg of animal weight.

11. Symptoms of overdose in animals have not been established.

12. With increased individual sensitivity of the animal to the antibiotics of the aminoglycoside group and the appearance of allergy signs (urticaria, diarrhea, angioedema), the drug is discontinued and desensitizing therapy is administered.

13. Passes should be avoided with the introduction of a regular dose of the drug, as this may lead to a decrease in therapeutic effectiveness. If one dose is missed, you must enter it as soon as possible. Further, the interval until the next administration of the drug does not change.

14. When streptomycin sulfate for injection is administered in accordance with this instruction, side effects and complications are generally not noted.

15. It is prohibited to use Streptomycin sulfate for injection in combination with other aminoglycoside antibiotics (neomycin, kanamycin, gentamicin).

16. Slaughter of animals for meat is allowed no earlier than 7 days after the last injection of the drug. The meat of animals, who were forcedly killed before the expiration of this period, can be used for feeding carnivores.

Milk, obtained from animals during the treatment period and within 2 days after the last injection of Streptomycin Sulfate for injection, is prohibited for use for food purposes. Such milk can be used after heat treatment for feeding animals.

IV. Personal prevention measures 

17. When working with the drug, you should follow the general rules of personal hygiene and safety, provided for when working with medicines.

18. Do not drink, smoke or eat while working with a medicine. After working with the drug, wash your hands with soap and water.

19. If the product gets on the skin or mucous membranes, they should be rinsed with plenty of running water. If accidentally swallowed, give a large amount of water to drink (4-5 glasses) and induce vomiting.

Permanent link to this article: http://biohimfarm.ru/en/antibakter_r/streptomicin/