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use of the drug “Waterton” atony and hypotension of hypothermia and bowel, bladder, and for prophylaxis and treatment of gynecological diseases of different etiology (to improve the tone of the uterus, the weakness of the labor attempts, the detention of the placenta in farm animals).

(Organization-developer: LLC Firm “Biochempharm”, Vladimir region, Raduzhny)

I. General information

1. Trade name of the medicinal product: Giteroton.

International nonproprietary name: 2[Aminocarbonyl] – N, N, n three methylethanamine chloride, sodium chloride.

2. Dosage form: solution for injection.

Giteroton contains in 100 ml as active substances-2 [Aminocarbonyl] – N, N, n three methylethanaminium chloride-50 mg, sodium chloride-900 mg and as an auxiliary substance water for injection.

3. Guiterotone in appearance is a colorless transparent liquid.

The shelf life of Heterotoma at observance of storage conditions in unopened container is 3 years from manufacturing date. After the first opening of the vial, the drug should be used within 12 hours.

It is forbidden to use Guiterotone after the expiration date.

4. Giteroton is produced packaged in 100 ml in glass bottles of appropriate capacity, capped with rubber stoppers, reinforced with aluminum caps. Each consumer package is accompanied by instructions for use.

5. Giteroton is stored in the closed packaging of the manufacturer in a dry place protected from direct sunlight, separate from food and feed, at a temperature of 5ºC to 25ºC.

6. Heterodon should be stored in places inaccessible to children.

7. Unused drug is disposed of in accordance with the requirements of the legislation.

8. It is released without a prescription of a veterinarian.

II. Pharmacological properties

9. Waterton refers to pharmacological group M – and n-cholinomimetics.

10. Giteroton refers to drugs acting on peripheral cholinergic structures, stimulating the end of M – and N-cholinoreceptors (cholinomimetic), increases the contraction of the smooth muscles of the uterus, gastrointestinal tract, bladder and other organs. It does not penetrate the blood-brain and placental barriers.

Giteroton on the degree of exposure to the body refers to substances of low hazard (hazard class 4 according to GOST 12.1007-76), in the recommended doses does not have a locally irritating, resorptive-toxic sensitizing effect.

III. The order of application

11. Giteroton is used for atony and hypotension of the pancreas and intestines, bladder, for the treatment of subinvolution of the uterus, endometritis of various etiologies, with weakness of birth attempts, with the detention of the afterbirth in animals.

12. Contraindications to the use of Guiterotone is individual hypersensitivity of the animal to the components of the drug.

Giteroton can not be used in animals in which the gastrointestinal tract is crowded with tympanum, with convulsions, heart and respiratory diseases, acute infectious diseases and in the second half of pregnancy. With caution-an emaciated animal.

13. Guiterotone is administered to female animals subcutaneously or intramuscularly in the following doses:

Cows and mares:

– when detaining the afterbirth-1.5 ml per 100 kg of live weight (but not more than 8.0 ml per head of cattle), 3-4 hours after the release of the fetus, and then after 24 hours.

– for endometritis-1.5 ml per 100 kg three times in 48 hours;

– with ovarian cyst-1.0 ml per 100 kg twice in 72 hours;

– at weakness of patrimonial attempts-on 0,8 ml on 100 kg three times with an interval of 1 hour;

– for the evacuation of inflammatory exudate from the uterine cavity 1.5 ml per 100 kg 10-12 hours before the introduction of the drug into the uterus and 24 hours after administration.

Pigs: with similar pathological conditions, Guiterotone is administered subcutaneously 0.05-0.10 ml per 10 kg.

Large dogs: with similar pathologies Waterton administered subcutaneously based of 0.03-0.05 ml per 10 kg of live weight.

It is not allowed to use Giterotona more than 1 time in 24 hours, do not exceed the recommended dosage (maximum dose per 1 head of cattle-8 ml).

To achieve the best effect, complex treatment with antibiotics, ichthyglyuvitis and other drugs according to the indications, complete feeding, therapeutic exercise, and uterine massage is necessary.

14. Under overdose and have weakened animals are observed phenomena in the form of dyspnea, enteritis, salivation, anxiety, narrowing pupils, which pass on their own through 7-12 hours. If this does not happen, enter atropine sulfate at a dose of 5.0 mg per 100 kg of live weight.

15. Features of action at the first introduction of a drug and at its cancellation are not revealed.

16. Waterton is contraindicated in pregnant animals.

17. Skipping the administration of the drug should be avoided, as this can lead to a decrease in its therapeutic effectiveness.

18. The drug may cause painful irritation at the site of administration.

There may be rare cases of hypersensitivity to the components included in the composition of Guiterotone. In case manifestations of anaphylactic reaction animal, immediately introduce subcutaneously epinephrine 0.1 % from calculation 0.03-0.05 ml/kg living masses. According to the indications, use atropine, diphenhydramine, caffeine.

19. Waterton it is not recommended to use simultaneously with other myotonic means. The drug can not be used in conjunction with cholinomimetics and anticholinesterase agents.

20. During the application of Heterotoma livestock products can be used without restrictions.

IV. Personal prevention measures

21. When working with Guiterotone, the General rules of personal hygiene and safety, provided for when working with drugs, should be observed.

22. When working with the drug, it is forbidden to drink, smoke, eat.

At the end of work hands should wash warm water with soap.

People with hypersensitivity to the components of the drug should avoid direct contact with Guiterotone.

Empty packaging of the drug is prohibited to be used for household purposes, it is subject to disposal with household waste.

23. In case of accidental contact of the drug with the skin or mucous membranes of the eye, immediately rinse them with plenty of water. In case of allergic reactions or accidental ingestion of the drug in the human body, you should immediately contact a medical institution (with the instructions for use of the drug or the label).

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