INSTRUCTIONS

of using Novocaine 0.5%, 1%, 2% solution for injection

as a local anesthetic for animals

(Organization-developer:  “BioKhimPharm”, Raduzhny, Vladimir region).

I. General information

1. Trade name of the drug: Novocaine 0.5%, 1%, 2% solution for injection (Novocaini 0.5%, 1%, 2% solutio pro injectionibus).

International non-proprietary name: procaine hydrochloride.

2. Dosage form – injection solution.

Novocain 0.5%, 1%, 2% solution for injection as active ingredient in 100 ml contains respectively 0.5; 1.0; 2.0 g of procaine hydrochloride, and as a solvent water for injection. In appearance, the preparation is a clear, colorless liquid.

3. Novocain 0.5%, 1%, 2% injection for 1, 2, 5, 10, 20 ml in glass ampoules, packed in 10 pieces in a cardboard box and 5, 10, 20, 50, 100 ml in bottles, 200, 250, 400, 500 ml in bottles, sealed with rubber stoppers, reinforced aluminum caps.

4. Store the drug in a sealed manufacturer’s packaging, separate from food and feed, in a dry, protected from light place, at temperatures from 00C to 250C.

The shelf life of the medicinal product under the storage conditions is 3 years from the production date. It is forbidden to use Novocaine 0.5%, 1%, 2% solution for injection after the expiry date.

5. Novocain 0.5%, 1%, 2% solution for injection should be stored in places inaccessible to children.

6. Dispose of unused product in accordance with legal requirements.

II. Pharmacological properties

7. Novocaine belongs to the group of local anesthetics.

Novocaine blocks sodium channels, displaces calcium from receptors located on the inner surface of the membrane and, thus, prevents the generation of pulses in the endings of the sensory nerves and impulses along nerve fibers. Suppresses carrying out not only pain, but also impulses of another modality. With intravenous administration it has a general effect on the animal’s organism, reduces the formation of acetylcholine and reduces the excitability of peripheral cholinergic systems, has a blocking effect on vegetative ganglia, reduces spasms of smooth muscles, lowers the excitability of the heart muscle and the excitability of the motor cortex of the cerebral cortex. In toxic doses causes excitation, then paralysis of the central nervous system.

In the body, it rapidly hydrolyses, forming para-aminobenzoic acid and diethylaminoethanol, which are pharmacologically active substances.

After administration, the drug acts quickly and briefly. In terms of the effect on the organism Novokain 0.5%, 1%, 2% solution for injection refers to substances of low hazard (hazard class 4, Novocaine powder – substances highly hazardous (hazard class 2) according to GOST 12.1.007-76.

III. The order of application

8. Novocaine 0.5%, 1%, 2% solution for injection is used, if necessary, previously diluted with sterile saline to the desired concentration, for infiltration anesthesia in the form of 0.25% -0.5% solution; for anesthesia by the method of A.V. Vishnevsky (tight creeping infiltration) – 0,125% -0,25%; for conductor and spinal anesthesia 1% -2%.

In ophthalmology, 0.5% solution of novocaine is used for keratitis, keratoconjunctivitis, periodic inflammation of the eyes in horses (infraorbital blockade).

In the obstetric-gynecological practice, solutions of novocaine are prescribed for endometritis, metritis, prolapse of the uterus and vagina, detainment of the afterbirth in cows and goats (paranephalic blockade according to AV Vishnevsky), with serous-catarrhal mastitis (blockade of the udders of the udder according to BA Bashkirov or DD Logvinov) in the form of a 0.25% -0.5% solution.

Novocaine 0.5%, 1%, 2% solution for injection is also used as a solvent for medicines.

9. Contraindications to the use of Novocaine 0.5%, 1%, 2% solution for injection is not established, except for individual hypersensitivity to procaine.

10. Novocaine solutions are applied subcutaneously (0.25% -0.5%), intramuscularly (1% -2%).

The concentration of the solution, the dose, the method of application depends on the nature of the surgery or the course of the disease, the type, weight, age of the animal and its condition.

With local anesthesia, the toxicity of novocaine is higher, the more concentrated the solution is. In connection with this, with increasing solution concentration, the total dose is reduced or diluted standard solution of the drug to a lower concentration (0.125% -0.25%) with sterile isotonic sodium chloride solution 0.9% or Ringer-Lock. These dilutions are prepared immediately before use.

The maximum dose of novocain in ml per animal:

Repeated administration of solutions of novocaine is performed according to indications, but not earlier than 24 hours after the first administration.

11. In case of an overdose novocaine causes excitation, then – central nervous system paralysis. In these cases, drugs that stimulate the cardiovascular and respiratory system, infusion solutions are used.

12. Features of the drug during its first use and cancellation is not established.

13. The drug is used, as a rule, once.

14. In recommended doses does not cause side effects and complications in animals.

15. The use of Novocaine 0.5%, 1%, 2% solution for injection does not exclude the use of other drugs. Do not use together with sulfonamides.

16. Products of animal origin obtained from animals after application of Novocain 0.5%, 1%, 2% solution for injection can be used without restrictions.

IV. Personal prevention measures

17. When working with Novocain 0.5%, 1%, 2% solution for injection, you should follow the general rules of personal hygiene and safety, provided for working with medicines.

18. In case of accidental contact with the skin or mucous membranes of the eye, rinse immediately with plenty of water. People with hypersensitivity to procaine should avoid direct contact with Novocain 0.5%, 1%, 2% solution for injection. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (with you to have instructions for the use of the drug and a label).

19. It is prohibited to use empty containers for household purposes; it must be disposed of with household waste.