INSTRUCTIONS
on the use of the drug “Ophthalmol” in veterinary medicine for the treatment of animals (cattle, sheep, dogs, cats, rabbits), patients with ophthalmic diseases of infectious etiology; treatment of otitis parasitic etiology in dogs, cats and rabbits; treatment and prevention of miases in cattle, dogs, cats, rabbits.
(Developer organization: biohimpharm LLC, Raduzhny, Vladimir region)
I. General information
1. trade name of the medicinal product: Ophthalmol. International nonproprietary name: ivermectin, tylosin tartrate, xeroform.
2. Dosage form: topical ointment. The drug as active substances in 1 g contains: ivermectin-2.5 mg, tylosin tartrate-10 mg, xeroform-10 mg and auxiliary substances: tylose, twin-80, purified water.
3. In appearance the drug is a homogeneous viscous liquid yellow color.
Shelf life (after the first opening of the container) — in a tightly closed container of the manufacturer, subject to the recommended storage conditions until the expiration date. If the recommended storage conditions are met, the shelf life of the medicinal product is 2 years from the date of manufacture. It is forbidden to use Ophthalmol after the expiration date.
4. the Drug is produced packaged in plastic syringes-dispensers of 4, 10, 20, 30 ml, dark glass bottles hermetically sealed with rubber stoppers and rolled with aluminum caps with a pipette of 4, 10, 20, 30 ml.
5. Store the drug in the manufacturer’s closed packaging in a dry place protected from light, at a temperature of 5°C to 25°C.
6. Oftalmol should be stored in places inaccessible to children.
7. an Unused product with an expired expiration date is disposed of in accordance with the current legislation.
8. Available without a veterinarian’s prescription.
II. Pharmacological properties
9. Ophthalmol is a complex drug that has a bactericidal, anti-inflammatory, nematodocidal, acaricidal, insecticidal and repellent effect.
10. Ivermectin belongs to the chemical group of macrocyclic lactones and has a wide spectrum of antiparasitic action. It is active against gastrointestinal and pulmonary nematodes, lice, Ixodes and scabies mites, hypodermic and nasopharyngeal gadfly larvae, carrion flies, etc. The mechanism of action ivermectina based on paralysis of the muscles of the parasite due to increased allocation and binding of γ-aminobutyric acid involved in the transmission of impulses in the neuromuscular synapses of the parasite, leading to disruption of sodium channels, which causes the death of Mature and larval stages of the parasite. Ivermectin also has an anti-inflammatory effect by suppressing the production of Pro-inflammatory cytokines induced by lipopolysaccharides. Pharmacokinetic parameters are characterized by rapid distribution in the body and long-term elimination, which provides a permanent parasitocidal effect for 12-14 days. Ivermectin slowly and in a limited amount penetrates into the environment of the eye. The half-life is 28 hours.
Tylosin is a macrolide antibiotic. Active against most gram – positive and some gram – negative bacteria: staphylococci (Sta-phylococcus spp.), streptococci (Streptococcus spp.), Corynebacterium (Corynebacterium spp.), Clostridium (Clostridium spp.), Pasteurella (Pasteurella spp.), Erysipelothrix (Erysi-pelothrix rhusiopathiae), fusobacteria (Fusobacterium spp.), Leptospira (Leptospira spp.), chlamydia (chlamidia spp.), serpulina hyodysenleriae, as well as Mycoplasma (Mycoplasma spp.), actinomycetes (actinomycespyogenes) and some others. The mechanism of action of the drug is based on the inhibition of protein synthesis in the microbial cell, by blocking the translocase enzyme.
Xeroform is a bismuth salt and together with an antibiotic suppresses the second infection, as well as accelerates the healing and regeneration of damaged tissues, shows repellent, disinfecting, astringent and drying effects.
According to the degree of exposure to the body, the drug Ophthalmol belongs to low-hazard chemicals (hazard class 4 according to GOST 12. 1. 007).
III. Application procedure
11. Ophthalmol is used for :
– treatment of cattle, dogs, cats, rabbits for ophthalmic diseases of parasitic and bacterial etiology: telyaziosis, blepharitis (scaly and ulcerative), conjunctivitis (acute catarrhal, purulent, follicular), keratitis (superficial), kerato-conjunctivitis of infectious (rickettsiosis) and associative invasive-infectious (telyaziozno-microbial) etiology;
– treatment of dogs, cats and rabbits with otitis media of parasitic etiology (external ear-auricle, external auditory canal, middle ear): notoedres, otodectosis in, psoroptosis, the sarcoptic mange, chorioptes, cheilitis.
– treatment and prevention of cattle, sheep, dogs, cats, rabbits with miasma.
12. Contraindicated in animals with increased individual sensitivity to the active substances of the drug.
Preparations from ivermectin are toxic to collie, sheltie, Bobtail and their crossbreeds; they cause paralytic phenomena, which is associated with the encoding of the P-glycoprotein gene, which is responsible for the elimination of medications.
13. In case of increased individual sensitivity of the animal to the components of the drug and the development of allergic reactions, the use of the drug is discontinued and desensitizing therapy is performed.
14. the use of Ophthalmol does not adversely affect the course of pregnancy, lactation and development of offspring in animals.
15. when treating telyaziosis in cattle, the animal’s head is fixed so that the eye is on top, and a syringe-tube is slowly injected 0.8-1 ml of the drug into the conjunctival SAC, easily massaging. The course of treatment is 3-4 days, until full recovery. In case of inflammation of the eyelids, their edges are cleaned of scales and smeared with gel using a tampon.
For the treatment of other ophthalmic diseases, apply 5-7 drops of the drug to the inner corner of the eye, the course is 4-7 applications every 12 hours. If blepharitis is caused by ticks, the course of treatment is repeated 2-3 times in 10 days, regardless of the results of the first treatment.
For otitis media, pre-cut the hair in the animal’s ear, remove the scales and use a tampon to apply gel to the affected areas of the skin 2 times a day. Treatment is carried out 3-4 days before full recovery. Both ears are treated at the same time. If the disease is caused by ticks, the treatment is repeated after 8-10 days during the day.
To prevent wohlfahrtia in summer, the fresh wounds of animals smeared with gel. Wounds infested with fly larvae are treated 2 times a day until complete healing (3-4 days).
16. When applying Oftalmol in accordance with this instruction side effects and complications were noted.
17. Symptoms of overdose in animals were not detected. Application
18. the use of the drug does not exclude the simultaneous administration of other medications.
19. Features of the action of the drug at the first reception or when it is canceled: not established.
20. you should avoid skipping the next dose of the drug, as this may lead to a decrease in therapeutic effectiveness.
21. animal Products during and after the use of Ophthalmol may be used without restrictions.
IV. personal prevention Measures
22. when working with Ophthalmol, follow the General rules of personal hygiene and safety provided for when working with veterinary medicines.
23. When working with the preparation do not drink, smoke and eat. After working with the drug, wash your hands with soap and water.
24. People with hypersensitivity to the components of the drug should avoid direct contact with it. If the drug accidentally gets on the skin and/or mucous membranes, it is recommended to wash them with plenty of running water. If accidentally swallowed, give the affected person a large amount of water (4-5 glasses) and cause vomiting. In case of allergic reactions, you should immediately contact a medical institution (have the instructions for use of the drug and the label).
