INSTRUCTION
for use of the medicinal preparation “Metrofulin BHF” in veterinary medicine
(Organization-developer: LLC Firm “Biochempharm”, Vladimir region, Raduzhny)
I. General information
1. Trade name of the drug: Metrofulin BHF.
International nonproprietary name: metronidazole, oxytetracycline hydrochloride and furazolidone
2. Dosage form: powder for oral use. In 1 g of the drug as active substances contains 110 mg of metronidazole, 25 mg of oxytetracycline hydrochloride, 10 mg of furazolidone, and as excipients ascorbic acid, crystalline glucose.
3. In appearance, the drug is a powder of light yellow color.
Shelf life of the drug under the conditions of storage in a closed package-2 years from the date of production.
4. Metrofulin BHF is produced packaged in 50 g, 100 g, 200 g, 500 g, 1 kg in hermetically sealed polymer cans or bags.
5. Metrofulin BHF is stored in a closed manufacturer’s package in a dry, dark place at a temperature of 5 °C to 25 °C.
6. Metropolis BHP should be stored in places inaccessible to children.
7. Unused drug with expired shelf life is disposed of in accordance with the requirements of the legislation.
8. It is released without a prescription of a veterinarian.
II. Pharmacological properties
9. Pharmacotherapeutic group: antimicrobial drugs in combination.
10. Metronidazole has a wide spectrum of action against protozoa and causative agents of anaerobic infections. It is quickly absorbed and accumulates in the blood, then enters the liver and bile is released into the small intestine, where it is again absorbed and enters the blood. Partially excreted in the urine.
Oxytetracycline hydrochloride active against gram-positive and gram-negative bacteria, will tranem, Leptospira, rickettsiae and large viruses. The mechanism of antibacterial action is based on inhibition of protein biosynthesis of microbial cells. When taken orally, it is quickly absorbed and relatively long stored in the body. It is excreted mainly through the gastrointestinal tract and kidneys. Easily penetrates the placental barrier.
Furazolidone has a wide spectrum of action, effective against a number of microbes resistant to antibiotics and sulfonamides. Especially sensitive to it causative agents of dysentery and salmonellosis. Resistance to it of microorganisms develops slowly.
The constituent ingredients of the drug are well compatible and mutually enhance the antimicrobial effect. Bacteriostatic concentrations, against the background of recommended doses, are retained in the serum for 12 hours. Metronidazole and furazolidone also have an antimicrobial effect in the gastrointestinal tract.
III. The order of application
11. The drug is used for pigs as a therapeutic and prophylactic agent for colibacteriosis, salmonelesis, dysentery, bacterial enterocolitis, for the treatment of turkeys and goslings with histomonosis, for the treatment of chickens suffering from colibacteriosis and salmonelosis, as well as for the treatment of fish of the cyprinid family with aeromonosis and pseudomonosis. Other species of animals the drug can not be assigned.
12. The drug is contraindicated in hypersensitivity of animals and birds to its constituent components. With caution should be used in diseases of the liver and kidneys.
13. When working with the drug, the General rules of personal hygiene and safety, provided for when working with drugs, should be observed.
When working with Metropolia BHF do not drink, smoke and eat. After working with the drug, wash your hands with soap and water.
If the drug gets on the skin and mucous membranes, it is necessary to wash them with a large amount of tap water. People with hypersensitivity to the components of the drug should avoid direct contact with the drug. In case of allergic reactions and / or accidental ingestion of the drug in the human body should immediately contact a medical institution (with the instructions for use of the drug or label).
14. The drug is not used for the treatment of pregnant and lactating animals.
15. Piglets are prescribed the drug in the morning and evening feeding for 5-7 days. Under their treatment rate entry in feed accounts for 5 kg on ton. For prophylactic purposes, Metrofulin BHF is administered at the rate of 2 kg per ton of feed. Chickens, turkeys and geese Metrofulin BHF normalized at the rate of 2 kg per ton of feed for 5-7 days.
Fish administered in feed at a dose of 5 kg Metropolia BHF for one dose of feed during 5 days. Apply after a preliminary 12-hour soaking.
16. In compliance with the dosing regimen, the method of administration and administration of the drug, side effects and adverse reactions have not been established.
17. When applying Metropolia BHF in accordance with this instruction, the overdose symptoms are not marked.
18. The use of the drug does not exclude the use of other drugs.
19. Features of the action of the drug at the beginning of use or when it is canceled is not revealed.
20. You should avoid skipping the next dose of the drug, as this can lead to a decrease in therapeutic effectiveness. In the case of skipping one or more doses of the drug as early as possible resume in the same dosage and according to the same scheme.
21. Slaughter of animals and poultry for meat is allowed not earlier than 45 days after the last application of the drug.
In case of forced slaughter at an earlier date, it can be fed to carnivores.
Industrial fishing should be carried out not earlier than 45 days after the last application of the drug.
IV. Personal prevention measures
22. When working with the drug, the General rules of personal hygiene and safety, provided for when working with drugs, should be observed.
23. When working with Metropolia BHF do not drink, smoke and eat. After working with the drug, wash your hands with soap and water.
24. If the drug gets on the skin and mucous membranes, it is necessary to wash them with a large amount of tap water. People with hypersensitivity to the components of the drug should avoid direct contact with the drug. In case of allergic reactions and / or accidental ingestion of the drug in the human body should immediately contact a medical institution (with the instructions for use of the drug or label).
