INSTRUCTIONS
of using “Progesterone” for animals
(Organization-developer: “BioKhimPharm”, Vladimir region, Raduzhny town)
I. General information
1. Trade name of the medicinal product: Progesterone.
International non-proprietary name: progesterone.
2. Dosage form: solution for injection is oily.
In appearance, Progesterone is a transparent, yellowish-colored liquid. The drug contains 25 mg of progesterone (2.5%) in 1 ml as an active ingredient and 0.2 ml of benzyl benzoate, up to 1 ml of olive oil.
3. Progesterone is packaged in 1 ml and 10 ml in sterile hermetically sealed glass bottles, sealed with rubber stoppers and rolled with aluminum caps.
Each unit of packaging is marked with the name of the manufacturer, its address and trademark, the name of the medicinal product, the name and content of the active substances, the method of use, the serial number, the date of manufacture, the expiration date, the amount of the preparation in the vial, storage conditions, the inscriptions “Sterile” , “For veterinary use”, designations of technical specifications, bar code and accompany the instruction for use.
4. Store the preparation in the manufacturer’s closed container, in a dry, protected from light place at a temperature of 50C to 200C.
The shelf life of Progesterone under the storage conditions is 5 years from the date of manufacture. Do not use the drug after the expiration date.
5. Progesterone should be stored out of the reach of children.
6. Dispose of unused product in accordance with legal requirements.
II. Pharmacological properties
7. Pharmacotherapeutic group of the drug: sex hormones, progesterones. The drug has the biological and therapeutic effect of the natural hormone of the yellow body: it reduces excitability and contraction of the uterine musculature, creates the necessary conditions for fertilization, reduces the sensitivity of the uterus to oxytocin, stimulates the functional activity of the breast.
After administration, the drug is rapidly absorbed from the injection site and distributed to the organs and tissues of the animal. Metabolised in the liver. It is excreted in urine 50-60% and with feces 10%.
According to the degree of influence on the body Progesterone according to GOST 12.1.007 refers to substances of low danger (class 4 hazard), does not have irritating effects on the tissue.
III. The order of application
8. Progesterone is used by animals to prevent abortion in the usual fallout, to inhibit estrus.
9. Contraindication to the use of Progesterone is hypersensitivity to the components of the drug.
10. The preparation is heated to 37 ° C to 40 ° C before use. Progesterone is administered intramuscularly or subcutaneously once a day for 4-7 days, intramuscularly or subcutaneously 1 times a day for 4-7 consecutive days at a rate of 0.025-0.1 g of active ingredient per animal in the form of an oil 2.5 solution. Doses of the drug in ml per kg of live weight:
| Type of animal |
Intramuscular or subcutaneous |
| Horses |
0,01 |
| Cattle |
0,01 |
| Small cattle |
0,01 |
| Pigs |
0,015 |
| Dogs |
0,002 |
In the absence of ovulation and unproductive inseminations, progesterone is administered subcutaneously to the cows in a dose of 0.5 ml of a 2.5% solution twice per day at the beginning of the hunt and to the initial phase of formation of the yellow body.
11. Symptoms of overdose when using the drug in accordance with this instruction are not noted.
12. Features of the drug at the beginning of the application or when it was abolished is not revealed.
13. Passage of the next dose of the drug should be avoided, as this may lead to a decrease in therapeutic effectiveness. In the case of missing one or more doses, the drug is resumed as soon as possible in the same dosage and according to the same schedule.
14. At recommended doses Progesterone does not cause side effects and complications in animals.
15. The use of the drug does not exclude the use of other drugs. Reduces the intensity of the action of drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropic hormones of the anterior lobe of the pituitary gland. With simultaneous use with barbiturates, a decrease in the action of progesterone is noted.
16. Livestock products are used without restriction during and after application of the progesterone solution.
IV. Personal prevention measures
17. When working with Progesterone, you should follow the general rules of personal hygiene and safety measures provided for working with animal medicines.
18. When working with the drug, it is forbidden to drink, smoke and eat. After working with the drug, wash your hands with soap and water.
19. If Progesterone hits mucous membranes or skin, rinse it with a jet of clean water and, if necessary, contact a doctor.
