INSTRUCTIONS
of using “Mastisany A, B, E.” in veterinary medicine (Organization-developer: “BioKhimPharm”, Vladimir region, Raduzhny).
1. GENERAL INFORMATION
1. Mastisan A – complex preparation of the following composition (per 1 dose of 5 ml): benzylpenicillin sodium salt – 100 000 units; streptomycin sulfate 100 100 U; sulfadimezin or norsulfazole – 0.35 g; Base to 5 ml. Mastisan B – a complex preparation of the following composition (per 1 dose of 5 ml): Neomycin sulfate – 25 000 units; Sulfadimezin 0.25 g; Methyluracil 0.35 g; Base to 5 ml. Mastisan E – a complex preparation of the following composition (per 1 dose of 5 ml): Erythromycin base – 25 000 units; Sulphadimezine 0.4 g; Base to 5 ml.
2. Preparations are an oily, with a specific smell, a suspension that stratifies during storage.
3. Let out packaged on 50-100 ml in glass bottles or on 10 ml in venerable syringes. Other packing is allowed upon agreement in the established order.
4. Drugs stored in a dry, protected from the light at a temperature of 0 to 20 ° С. The shelf life of the drugs: Mastisany A, E – 1.5 years; Mastisan B – 1 year.
II. PHARMACOLOGICAL PROPERTIES
5. Mastisans – A, -B, -E have a broad antibacterial spectrum of action: suppress the growth and development of streptococci, staphylococci and other pathogenic microorganisms. Assign for the treatment of various forms of udder inflammation, traumatic udder skin lesions and nipples.
III. PROCEDURE FOR USE OF PREPARATIONS
6. Before using the drug, milk from the patients quarters is given out, and the nipple is disinfected. On the damaged skin of the udder, the drug is applied superficially, after preliminary treatment of the affected area with disinfectant. The contents of the vial are warmed to 35-39 ° C, shaken carefully until a uniform suspension is obtained and injected into the diseased quarter of the udder through an elastic plastic catheter, which is put on the cannula of the syringe.
7. Depending on the severity of the disease, 1 to 4 doses (5-20 ml) are administered. After the administration of the drug, the nipple of the patient quarter of the udder is slightly massaged from the bottom up, displacing the drug from the nipple channel into the udder cistern. The administration of the drug is repeated every 24 hours, until the symptoms disappear completely.
8. Contraindications, side effects and complications in the application is not established.
9. During treatment and within 3 days after the last administration of the drug, milk from the affected parts of the udder is discharged into a separate bowl, degreased and disposed of, and from the rest – fed to the animals after boiling. Meat of animals killed during the treatment with the drug is used on a general basis, with the exception of the udder, which is rejected. The use of milk for human milk from the affected parts of the udder is allowed 3 days after the last administration of the drug, provided the clinical signs of mastitis completely disappear.
