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of using Sulfatrimet for the treatment of cattle, horses, camels, small horned cattle and pigs in diseases of bacterial etiology  

(Organization-developer: OOO Firma BioKhimPharm, 600910, Vladimir Region, Raduzhny, block 16, PO Box 74)  

I. General information  

1. Trade name of the medicinal product: Sulfatrimet.

International non-proprietary name: sulfadiazine, trimethoprim.

2. Dosage form: suspension for injection.

Sulfatrimet contains sulfadiazine, trimethoprim and auxiliary components as active ingredients.

3. In appearance, the preparation is a sterile suspension from white to yellowish white, exfoliating during storage. Shelf life of the drug under the storage conditions is 2 years from the date of manufacture. After opening the package, the drug should be stored for no more than 28 days. It is forbidden to use Sulfatrimet after the expiration date.

4. Produce Sulfatrimet packaged in 50, 100, 200 ml in glass bottles.

5. Store the medicinal product in the manufacturer’s closed packaging away from heating appliances, separate from food and feedstuffs, in a dry place protected from direct sunlight at a temperature of 50 ° C to 250 ° C.

6. Sulfatrimet should be kept out of the reach of children.

7. Dispose of unused product with expired shelf life in accordance with legal requirements.

8. Released without a veterinarian’s prescription.

II. Pharmacological properties  

9. Pharmacotherapeutic group of medicinal product: antimicrobial agent combined.

10. Sulfatrimet possesses a broad antibacterial spectrum of action against most Gram-positive and Gram-negative microorganisms, incl. E. coli, Salmonella spp., Staphylococcus spp., Streptococcus spp., Shigella spp. other microorganisms, as well as some protozoa such as Coccidia and Toxoplasma gondi. Sulfadiazine sodium disrupts the synthesis of dihydrofolic acid in bacterial cells, preventing the inclusion of para-aminobenzoic acid in its molecule. Trimethoprim enhances the action of sulfadiazine, disrupting the reduction of dihydrofolic acid to the tetrahydrofolic – active form of folic acid, responsible for protein metabolism and division of the microbial cell. With the combined action, the synthesis of folic acid in two consecutive stages is violated, which leads to a violation of the synthesis of nucleotides and causes the synergistic bactericidal action of the combination of sulfadiazine and trimethoprim

Sulfadimezin and trimethoprim, which are part of Sulfatimet, enhance the effect of each other by sequential action on the metabolism of n-aminobenzoic and folic acid in the microbial cell, providing a wide range of antibacterial action. Sulfatrimet is active against gram-positive and gram-negative microorganisms. With intramuscular injection, Sulfatrimete is resorbed and reaches its maximum concentration 2-3 hours after the injection. Antibacterial action persists for 24 hours. The drug is excreted from the body mainly with urine, in lactating animals – partly with milk.

In terms of the degree of exposure to the body, Sulfatrimet is classified as moderately hazardous by the degree of exposure to the body (hazard class 3 according to GOST 12.1.007).

III. The order of application  

11. Sulphatrimeth is used for the treatment of cattle, horses, camels, small cattle and pigs in the complex therapy of bacterial infections caused by microorganisms sensitive to the components of the drug, including diseases of the respiratory and genitourinary system, the digestive tract. Complex treatment of postoperative and postpartum complications, infections of the oral cavity (stomatitis, gingivitis) and otitis. It can be used for antibacterial treatment in surgical cases in which there are infections, for example, with an open fracture and in an established peritonitis.

12. Contraindications for use: increased individual sensitivity to sulfonamides. Do not administer to animals with severe hepatitis and nephropathy, with blood diseases, pregnant females. Contraindicated joint use of the drug with drugs containing derivatives of paraminobenzoic acid (novocaine, anesthesin), preparations of sulfur (sodium thiosulfate and unitiol) with salicylates, butadione. The drug is not used to treat dogs and cats.

13. Before use, the vial with suspension is vigorously shaken.

Sulfatrimeth is administered to the animal once a day intramuscularly at a dose of 16 mg / kg body weight of the animal (i.e., 1ml / 30 kg body weight) daily.

In acute infections, a dose of up to 24 ml / kg (ie: 1.5 ml / 30 kg) of body weight can be increased daily. If necessary, the suspension is administered repeatedly every day or every other day, depending on the clinical condition of the animal. The duration of the course of treatment is set individually by a veterinarian. For effective treatment of the disease it is recommended to conduct a laboratory test for the sensitivity of microorganisms isolated from the sick animal to antibacterial drugs, including sulfanilamides.

14. Symptoms of overdose in animals have not been identified.

15. Features of the drug during the first admission or when it is canceled: not established.

16. The use of Sulfatrimet does not adversely affect the course of pregnancy, lactation and development of offspring in animals.

17. Passage of the next dose of the drug should be avoided, as this may lead to a decrease in therapeutic effectiveness. If the interval between two injections of the drug is accidentally increased, it should be administered as soon as possible.

18. When applying Sulfatrimet in accordance with this instruction, side effects and complications, as a rule, are not observed. In some cases, allergic reactions (pruritus, erythema), vomiting, anorexia, diarrhea, dyspepsia, as well as changes in the hematological profile: thrombocytopenia, leukopenia and agranulocytosis, may occur in an animal with increased individual sensitivity to the components of the suspension, disturbance of the order of intake and dosing. When these signs appear, the drug should be discontinued. At the site of administration of the drug, an animal may develop a local reaction in the form of a minor edema, itching or erythema, which spontaneously disappears and does not require treatment. With increased individual sensitivity of the animal to the components of the drug and the development of allergic reactions, the drug is discontinued and desensitizing therapy is administered.

19. Sulfatrimet should not be mixed in the same syringe with other drugs, nor can it be used concurrently with bacteriostatic chemotherapeutic drugs.

20. Slaughter for meat of productive animals is allowed 10 days after the last use of the drug. Meat of animals, who were forced to die before the expiration of this period, can be used in fodder for fur animals or for processing for meat and bone meal. Milk of milk animals within 3 days after the last administration of Sulfatrimet is prohibited for use in food purposes, it can be used only after heat treatment in animal feed.

IV. Personal prevention measures  

21. When working with a medicinal product, the general rules of personal hygiene and safety precautions prescribed in dealing with medicinal products should be observed.

22. When working with Sulfatrimet it is forbidden to drink, smoke and eat. Avoid contact with skin and mucous membranes. After working with the drug, wash your hands with soap and water. Empty vials from the drug are not allowed for household use.

23. In case of accidental contact with the skin or mucous membranes, rinse immediately with plenty of water. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (with you to have instructions for the use of the drug and a label).

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