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of using Estropharm for the regulation and treatment of reproductive function in female farm animals

Organization-developer: “BioChimPharm”, 600910, Vladimir region, Raduzhny, quarter 16, PO Box 74

I. General information

1. Trade name of the medicinal product: Estropharm. International non-proprietary name: cloprostenol.

2. Dosage form: solution for injection. Estropharm contains as auxiliary cloprostenol and auxiliary substances.

3. In appearance, the preparation is a clear, colorless solution. Shelf life of the drug under the conditions of storage – 2 years from the date of manufacture. It is forbidden to use Estropharm after its expiration date.

4. Produce Estropharm prepacked in 2, 5, 10, 20, 50, 100, 200 ml in glass bottles.

5. Store the medicinal product in the manufacturer’s closed packaging away from heating appliances, separate from food and feedstuffs, in a dry place protected from direct sunlight at a temperature of 50 ° C to 250 ° C.

6. The estrofarm should be kept out of the reach of children.

7. Dispose of unused product with expired shelf life in accordance with legal requirements.

8. Released without a veterinarian’s prescription.

II. Pharmacological properties

9. Pharmacotherapeutic group of the drug: hormones and their antagonists.

10. Cloprostenol is a synthetic prostaglandin, a structural analogue of natural prostaglandin F2α (PGF2α). It has a strong luteolytic effect, causes functional and morphological regression of the yellow body (luteolysis), thereby relieving the inhibitory effect of progesterone on the hypothalamic-pituitary complex, promoting the growth of follicles in the ovaries, increasing the level of estrogens in the blood, the manifestation of hunting and the subsequent ovulation of mature follicles.

In the animal body, cloprostenol is rapidly metabolized and excreted in the urine within 24 hours. By the degree of effect on the organism, Estropharm refers to moderately hazardous substances (hazard class 3 according to GOST 12.1.007).

III. The order of application

11. Estrofarm is used to regulate the reproductive function and treatment of its pathologies in female farm animals, including: induction of sexual hunting in cows, mares, camels, induction of farrowing in sows; treatment of cows, mares and camels with various forms of ovarian dysfunction: persistent yellow body, follicular (in combination with chorionic or luteinizing hormones) and luteal cysts, ovarian hypofunction (in combination with gonadotropin releasing hormone, follicle stimulating hormone or gonadotropin medications of stallion mares) , prevention and treatment of postpartum diseases of the uterus. To terminate pregnancy in fetal pathologies.

12. Contraindication to the use of the drug is an established or presumed pregnancy of females, except for cases of interruption of unwanted pregnancy or induction of labor. With the premature use of the drug for the stimulation of labor, retention of the after

13. The drug is administered intramuscularly. Before the drug is used to regulate the reproductive function and synchronize the sexual cycle, a gynecological examination of the animals is performed. The drug is used only in households that are well off in an epizootic situation using disposable syringes. For the purpose of inducing the sexual cycle, Estrophasm is administered: – Cows in a dose of 2 ml (0.500 mg of cloprostenol) twice with an interval of 11 days.

The first dose is administered at any phase of the sexual cycle, the second – on the 11th day after the first application. Insemination of animals is carried out 72-76 hours after the second injection, twice with an interval of 12 hours; – mares, camels once in a dose of 1 ml (0.250 mg cloprostenol); – ponies once in a dose of 0.5-1 ml (0.125-0.250 mg of cloprostenol); – donkeys once in a dose of 0.5-1 ml (0.125-0.250 mg cloprostenol).

For synchronization of farrowing, Estropharm is administered to sows once in a dose of 0.7 ml (0.175 mg of cloprostenol) two days before farrowing. In 95% of the animals, the ripening occurs within a period of 36 hours after the injection of the drug. In order to treat functional disorders of the ovaries (persistent yellow body, luteal cyst), the drug is administered: – cows in a dose of 2 ml (0.500 mg of cloprostenol).

When hunting is detected, insemination is carried out. For animals that do not go hunting, the drug is given again at the same dose 11 days after the first application, followed by twice insemination 72 and 96 hours after the second administration of Estropharm; – mares, camels once in a dose of 1.0 ml (0.25 mg cloprostenol) in the period from 5 to 13 days of the onset of estrus (optimal period 4-6 days).

For the treatment of ovarian dysfunction (quiet hunting, violation of the periodic cycle, anovulatory cycle), Estrophag is administered: – Cows that did not go hunting after 50-60 days after calving in the absence of yellow bodies undergo combined therapy with gonadotropin preparations of blood serum of foal mares (GSWC) 800-1200 IE or Surfagon in a dose of 10 ml (50 μg) and simultaneous Estrofarm administration in a dose of 1 ml (0.250 mg cloprostenol). Cows who come to the hunting seed.

An animal that does not come into the hunting 11 days after the first administration of Estrophasm in the presence of yellow bodies is injected with the drug repeatedly at that dose, in the absence of a yellow body – GASC preparations are administered in combination with Estropharm in the same doses.

For the treatment of follicular cysts, Surfagon is administered subcutaneously or intramuscularly in a dose of 4-5 ml (20-25 μg) three times with an interval of 24 hours, after 10 days (240 hours) after the last administration, Estropham is administered at a dose of 4.0 ml (1 , 0 mg cloprostenol). The onset of estrus is noted on the 1st day after the administration of the drug. In case the use of the above scheme is difficult to implement, the drugs of human chorionic gonadotropin (hCG) at a dose of 3000 IU are administered once intramuscularly or once intravenously.

After 6 days (144 hours), Estrofarm is then administered in a dose of 4.0 ml (1.0 mg cloprostenol). For the prevention of postpartum diseases of the uterus (subinvolution and endometritis), estrophasm is administered: – to cows in a dose of 2 ml (0.500 mg cloprostenol) 6-8 hours after calving; – sows in a dose of 0,7 ml (0,175 mg cloprostenol) in 2-4 hours after separation of the afterbirth.

For the treatment of endometritis in cows, Estrophasm is administered in a dose of 2 ml (0.500 mg cloprostenol) in combination with etiotropic pathogenic and symptomatic therapy. With chronic endometritis, repeated administration of estrofarm after 10-14 days is possible to restore the function of the endometrium of the uterus.

To interrupt pregnancy in cows with fetal pathology, the drug is used in a dose of 2 ml (0.500 mg of cloprostenol) at any stage of pregnancy according to indications.

14. Symptoms of overdose in animals have not been identified.

15. Features of the drug during the first admission or when it is canceled is not established.

16. Passage of the next dose of the drug should be avoided, as this may lead to a decrease in therapeutic effectiveness. If the interval between two injections of the drug is accidentally increased, it should be administered as soon as possible.

17. When using the drug in accordance with this instruction, no side effects and complications have been identified. In mares, there may be a slight sweating, which disappears within 1 hour.

18. Estrophasm should not be mixed in the same syringe with other medicines, nor can it be used concomitantly with bacteriostatic chemotherapeutic agents.

19. Milk of cows, mares and camels after application of Estropharm can be used for food purposes without restrictions, animal meat – 24 hours after the last use of the drug. Meat of animals, who were forced to die before the expiration of this period, can be used in fodder for fur animals.

IV. Personal prevention measures

20. When working with a medicinal product, the general rules of personal hygiene and safety precautions provided for working with medicinal products should be observed.

21. When working with Estropharm it is forbidden to drink, smoke and eat. Avoid contact with skin and mucous membranes. After working with the drug, wash your hands with soap and water. Empty vials from the drug are not allowed for household use.

22. If the medicinal product is accidentally contacted with skin or mucous membranes, immediately flush with plenty of water. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (with you to have instructions for the use of the drug and a label).

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